Mid-Gestational Serum Leptin Concentration In Obese And Non-Obese Ghanaian Mothers And Its Relationship With Gestational Outcome

Authors

  • M.A. Nuamah
  • K. Adu-Bonsaffoh
  • K. Asah-Opoku
  • M. Atuahene
  • E. Korankye
  • M. Torto
  • S. Kitcher
  • A.E. Yawson
  • H. Asare-Anane
  • A. Samba

DOI:

https://doi.org/10.60014/pmjg.v9i2.234

Keywords:

Body Mass Index, Leptin, Mid-gestation, Parturition

Abstract

Background: Leptin is produced abundantly in adipose tissue and in human placental trophoblast so serum leptin concentration in BMI matched pregnant women is higher than non-pregnant women. The aim of the study was to compare serum leptin concentration of obese and non-obese pregnant Ghanaian women and to match it with pregnancy outcome.
Method: This was a nested case control study, for which 80 antenatal women grouped into obese (cases) and nonobese (control) based on their booking body mass index (non-obese≤29.9kg/m2<obese). The participants had their mid gestation (20-24 weeks) serum stored until delivery and serum leptin concentration of the first 20 cases and 20 controls who delivered at the study site were compared to examine if it had effect on gestational outcome. Correlation between leptin concentration, gestational age at delivery and birth weight were assessed using Spearman’s correlation coefficient.
Results: The ages, median (range) 31(20-39) of cases and controls 32 (17-40) were not significantly different. There was no significant difference between the serum leptin concentration of cases 1.9 (0.5-50) ng/ml and controls 1.9 (1.5-50) ng/ml (P>0.05) and these had no correlation with maternal BMI or with baby’s Apgar scores. Our study subsequently, found no correlation between maternal mid-gestational leptin concentration and gestational age at delivery, as well as with birth weight of neonates.
Conclusion: Mid-gestational leptin concentration did not correlate with BMI in pregnant Ghanaian women and our study failed to find correlation between midgestational leptin concentration and gestational age at delivery.

Author Biographies

M.A. Nuamah

Department of Obstetrics and Gynecology, University of Ghana Medical School, College of Health Science

K. Adu-Bonsaffoh

Department of Obstetrics and Gynecology, University of Ghana Medical School, College of Health Science

K. Asah-Opoku

Department of Obstetrics and Gynecology, University of Ghana Medical School, College of Health Science

M. Atuahene

Department of Population, Family and Reproductive Health, School of Public Health, College of Health Science, University of Ghana

E. Korankye

Department of Obstetrics and Gynecology, University of Ghana Medical School, College of Health Science

M. Torto

Department of Obstetrics and Gynecology, University of Ghana Medical School, College of Health Science

S. Kitcher

Department of Dietherapy, Korle Bu Teaching Hospital, Accra, Ghana

A.E. Yawson

Department of Community Health, University of Ghana Medical School, College of Health Science

H. Asare-Anane

Department of Chemical Pathology, School of Biomedical and Allied Health Science, College of Health Science, University of Ghana

A. Samba

Department of Obstetrics and Gynecology, University of Ghana Medical School, College of Health Science

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Published

2022-07-12

How to Cite

Nuamah, M., Adu-Bonsaffoh, K., Asah-Opoku, K., Atuahene, M., Korankye, E., Torto, M., Kitcher, S., Yawson, A., Asare-Anane, H., & Samba, A. (2022). Mid-Gestational Serum Leptin Concentration In Obese And Non-Obese Ghanaian Mothers And Its Relationship With Gestational Outcome. Postgraduate Medical Journal of Ghana, 9(2), 99–105. https://doi.org/10.60014/pmjg.v9i2.234

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